Disciplinas
Targeting cancer cells
Créditos: 2
Carga horária: 30 horas
Programa(s): Mestrado e Doutorado
Tipo: Ofertada
Período da Oferta: De 21/08/2019 a 23/10/2019
Docente(s): Glaucio Valdameri (Permanente)
Ementa
Chapters in this course cover the complexity of cancer drug resistance and the current strategies to target the Achilles Heel of cancer cells. Discussion about important concepts, such as: collateral sensitivity, ABC transporters, temporal sensitivity and metabolic crosstalk. in addition, the course will cover the main methodologies used in cancer research. Bibliografia Anon, 2016. Paul Workman: Drugging the Cancer Genome. Trends in Cancer, 2(10), pp.544?548. Chen, Z. et al., 2016. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Letters, 370(1), pp.153?164. Dolmans, D.E.J.G.J., Fukumura, D. & Jain, R.K., 2003. Photodynamic therapy for cancer. Nature Reviews Cancer, 3(May), pp.380?387. Gottesman, M.M. et al., 2016. Toward a Better Understanding of the Complexity of Cancer Drug Resistance. Annual Review of Pharmacology and Toxicology, 56(1), pp.85?102. Greaves, M. & Maley, C.C., 2012. Clonal evolution in cancer. Nature, 481(7381), pp.306?313. McGranahan, N. & Swanton, C., 2017. Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future. Cell, 168(4), pp.613?628. Szakács, G. et al., 2006. Targeting multidrug resistance in cancer. Nature Reviews, 5(March), pp.219?234. Szakács, G. et al., 2014. Targeting the achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance. Chemical Reviews, 114(11), pp.5753?5774. Trachootham, D., Alexandre, J. & Huang, P., 2009. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nature Reviews Drug Discovery, 8(7), pp.579?591. Zhao, B. et al., 2016. Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution. Cell, 165(1), pp.234?246.Informações
Número máximo de alunos: 15
Local: Laboratório de Imunologia Clínica
Data: 21/08, 25/09, 02/10, 09/10, 16/10 e 23/10
Horário: 13:30 às 18:30h
Número de créditos: 2
